A review on artificial intelligence in high-speed rail

High-speed rail (HSR) has brought a number of social and economic benefits, such as shorter trip times for journeys of between one and five hours; safety, security, comfort and on-time commuting for passengers; energy saving and environmental protection; job creation; and encouraging sustainable use of renewable energy and land. The recent development in HSR has seen the pervasive applications of artificial intelligence (AI). This paper first briefly reviews the related disciplines in HSR where AI may play an important role, such as civil engineering, mechanical engineering, electrical engineering and signalling and control. Then, an overview of current AI techniques is presented in the context of smart planning, intelligent control and intelligent maintenance of HSR systems. Finally, a framework of future HSR systems where AI is expected to play a key role is provided

Quantum-Classical Crossover and Apparent Metal-Insulator Transition in a Weakly Interacting 2D Fermi Liquid

We report the observation of a parallel magnetic field induced metal-insulator transition (MIT) in a high-mobility two-dimensional electron gas (2DEG) for which spin and localization physics most likely play no major role. The high-mobility metallic phase at low field is consistent with the established Fermi liquid transport theory including phonon scattering, whereas the insulating phase at higher field shows a large negative temperature dependence at resistances much smaller than the quantum of resistance, $h/e^2$. We argue that this observation is a direct manifestation of a quantum-classical crossover arising predominantly from the magneto-orbital coupling between the finite width of the 2DEG and the in-plane magnetic field.Comment: 4 pages, 2 figure

Transcriptional Profiling of Saccharomyces cerevisiae Reveals the Impact of Variation of a Single Transcription Factor on Differential Gene Expression in 4NQO, Fermentable, and Nonfermentable Carbon Sources

Cellular metabolism can change the potency of a chemical’s tumorigenicity. 4-nitroquinoline-1-oxide (4NQO) is a tumorigenic drug widely used on animal models for cancer research. Polymorphisms of the transcription factor Yrr1 confer different levels of resistance to 4NQO in Saccharomyces cerevisiae. To study how different Yrr1 alleles regulate gene expression leading to resistance, transcriptomes of three isogenic S. cerevisiae strains carrying different Yrr1 alleles were profiled via RNA sequencing (RNA-Seq) and chromatin immunoprecipitation coupled with sequencing (ChIP-Seq) in the presence and absence of 4NQO. In response to 4NQO, all alleles of Yrr1 drove the expression of SNQ2 (a multidrug transporter), which was highest in the presence of 4NQO resistance-conferring alleles, and overexpression of SNQ2 alone was sufficient to over- come 4NQO-sensitive growth. Using shape metrics to refine the ChIP-Seq peaks, Yrr1 strongly associated with three loci including SNQ2. In addition to a known Yrr1 target SNG1, Yrr1 also bound upstream of RPL35B; however, overexpression of these genes did not confer 4NQO resistance. RNA-Seq data also implicated nucleotide synthesis pathways including the de novo purine pathway, and the ribonuclease reductase path- ways were downregulated in response to 4NQO. Conversion of a 4NQO-sensitive allele to a 4NQO-resistant allele by a single point mutation mimicked the 4NQO-resistant allele in phenotype, and while the 4NQO resistant allele increased the expression of the ADE genes in the de novo purine biosynthetic pathway, the mutant Yrr1 increased expression of ADE genes even in the absence of 4NQO. These same ADE genes were only increased in the wild-type alleles in the presence of 4NQO, indicating that the point mutation activated Yrr1 to upregulate a pathway normally only activated in response to stress. The various Yrr1 alleles also influenced growth on different carbon sources by altering the function of the mitochondria. Hence, the complement to 4NQO resistance was poor growth on nonfermentable carbon sources, which in turn varied depending on the allele of Yrr1 expressed in the isogenic yeast. The oxidation state of the yeast affected the 4NQO toxicity by altering the reactive oxygen species (ROS) generated by cellular metabolism. The integra- tion of RNA-Seq and ChIP-Seq elucidated how Yrr1 regulates global gene transcription in response to 4NQO and how various Yrr1 alleles confer differential resistance to 4NQO. This study provides guidance for further investigation into how Yrr1 regulates cellular responses to 4NQO, as well as transcriptomic resources for further analysis of transcription factor variation on carbon source utilization

Catalytic Enantioselective Stereoablative Alkylation of 3-Halooxindoles: Facile Access to Oxindoles with C3 All-Carbon Quaternary Stereocenters

From 2 to 1! Racemic tertiary halooxindoles proceed to enantioenriched oxindoles bearing all-carbon quaternary stereocenters as a result of a catalytic enantioselective stereoablative process (see scheme). The application of this procedure allows for the rapid asymmetric construction of biologically significant alkaloid core motifs

Transmission electron microscopy structure and platinum-like temperature coefficient of resistance in a ruthenate-based thick film resistor with copper oxide

As an alternative to thin-film platinum temperature sensor elements, thick film resistor ones are of interest for circuits which can withstand a near-engine environment. From a pyrochlore paste (DuPont 5091D), a close match is obtained (after firing) to the positive temperature coefficient of resistance (TCR) of Pt. Within the glassy matrix during 850 °C850 °C firing, needle-like RuO2RuO2 grains grow by a mechanism consistent with periodic bond chain theory. The acicular growth habit is attributed to a Cu2OCu2O additive, which is assumed to oxidize upon firing. The needles provide direct paths for metallic conduction and a characteristic positive TCR to the thick film in spite of having a low RuO2RuO2 volume fraction. © 2000 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70506/2/JAPIAU-88-2-1124-1.pd

Microwave-Assisted Oxidation of Electrospun Turbostratic Carbon Nanofibers for Tailoring Energy Storage Capabilities

We report the systematic structural manipulation of turbostratic electrospun carbon nanofibers (ECNFs) using a microwave-assisted oxidation process, which is extremely rapid and highly controllable and affords controlled variation of the capacitive energy storage capabilities of ECNFs. We find a nonmonotonic relationship between the oxidation degree of ECNFs and their electrocapacitive performance and present a detailed study on the electronic and crystalline structures of ECNFs to elucidate the origin of this nonmonotonic relation. The ECNFs with an optimized oxidation level show ultrahigh capacitances at high operation rates, exceptional cycling performance, and an excellent energy–power combination. We have identified three key factors required for optimal energy storage performance for turbostratic carbon systems: (i) an abundance of surface oxides, (ii) microstructural integrity, and (iii) an appropriate interlayer spacing